Northern Territory Police have arrested two men after the seizure of 1.3kg of MDMA, 130 grams of Ketamine and 19.5 grams of LSD.

A further $275,760 in cash, 6 mobile phones and other items indicative of drug supply were located during the search.

Drug and Organised Crime Detectives executed the search warrant at a residence in Driver yesterday where the pair of 21-year-olds, who are known to each other, were arrested and charged with numerous drug offences.

Investigators also confirmed the men supplied approximately 5kgs of MDMA throughout Darwin in the last 4-6 months.   

The pair were remanded to appear in Darwin Local Court today.